C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/279
C07D 487/14 (2006.01) A61K 31/40 (2006.01)
Patent
CA 1337767
The present invention provides indolocarbazole deriva- tives of the general formula I: Image (I) wherein R1 and R2, which can be the same or different, are hydrogen atoms, straight-chained or branched alkyl radicals containing up to 6 carbon atoms; benzyl radicals; aminoalkyl radicals containing up to 12 carbon atoms, which radicals are unsubstituted or are substituted on a carbon atom by a hydroxy group, a C1-C4 alkyl group or a C1-C4 alkoxy group or are substi- tuted on the amino nitrogen atom by C1-C4 alkyl or benzyl, or the amino nitrogen atom forms part of a heterocyclic ring that can optionally contain an oxygen atom or a further nitrogen atom; alkoxycarbonylalkyl radicals containing up to 6 carbon atoms; -CH2-CO-NR3R4 radicals, wherein R3 and R4 are the same or different and signify hydrogen atoms, alkyl radicals containing up to 4 carbon atoms or benzyl radicals; or R1 and R2 are haloalkyl; hydroxyalkyl or alkoxyalkyl radicals with, in each case, up to 6 carbon atoms; a benzoylalkoxyalkyl-, acetyloxyalkoxyalkyl- or hydroxyalkoxyalkyl radical with, in each case, up to 11 carbon atoms or acyl radicals containing up to 4 carbon atoms, or R1 and R2 together signify an alkylene radical containing 2 to 4 carbon atoms which may be unsubstituted or substituted by hydroxy, C1-4- alkoxy or amino and X and Y are the same and both signify hydrogen atoms or X and Y are different, one of them being a hydrogen atom and the other being a hydroxyl group or an alkoxy radical contain- ing up to 4 carbon atoms, with the proviso that all of the symbols R1, R2, X and Y do not simultaneously signify hydrogen atoms; as well as the pharmacologically acceptable salts thereof. The com- pounds are potent inhibitors of protein kinases and can be used, for example, for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, inflammatory processes, allergies, cancers and certain degenerative diseases of the central nervous system. The present invention also provides processes for the preparation of these compounds and pharmaceu- tical compositions containing them.
590001
Barth Hubert
Hartenstein Johannes
Kleinschroth Jurgen
Rudolph Claus
Schachtele Christoph
Godecke Aktiengesellschaft
Smart & Biggar
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