Process for preparing antibiotic l 17392 (deglucoteicoplanin)

Details Process for preparing antibiotic l 17392 (deglucoteicoplanin) Process for preparing antibiotic l 17392 (deglucoteicoplanin)

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/64 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1250096

ABSTRACT Process for preparing antibiotic L 17392 by catalyti- cally hydrogenating a deglucoteicoplanin ester of formula Image Formula II wherein A, B and Z represent hydrogen atoms, R represents benzyl or substituted benzyl, wherein the phenyl group is substituted with at least a substituent selected from chloro, bromo, fluoro, nitro, (C1-C3)alkyl, (C1-C3)alkoxy and the like, with the exclusion of the tri-nitro phenyl group, or acid addition salts thereof, to catalytic hydrogenolysis in the presence of a poisoned hydrogenation catalyst at a temperature from 10°C to 40°C and a pressure between ambient pressure and 5 atm, in an inert organic solvent preferably in the presence of a mineral acid.

483726

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