Quinoline derivatives, their preparation and therapeutic...

Details Quinoline derivatives, their preparation and therapeutic... Quinoline derivatives, their preparation and therapeutic...

C - Chemistry, Metallurgy

07

D

167/226, 260/283

C07D 215/56 (2006.01) A61K 31/47 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1291136

A B S T R A C T The invention relates to new quinoline derivatives of the formula : Image wherein R stands for C2H5, C2H4F, CH2-O-CH2-CH2OH, CH2 Image , Image , Image or Image to a process for their preparation comprising reacting, for 12-24 hours, at 70 - 95°C, in dimethylformamide, the 1,4-dihydro- 3-ethoxycarbonyl- 6,8- difluoro-4-oxo-quinoline with an excess of RX (2-5 mol of RX for one mol of quinoline), in the presence of K2CO3 and subsequently hydrolysing the obtained 3-ester by HCl under reflux conditions and to pharmaceutical compositions comprising at least one 1,4-dihydro- 3-carboxy- 6,8-difluoro- 1-R-4-oxo-quinoline derivative in admixture with a pharmaceutically acceptable diluent or carrier.

481189

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