Analgesic compounds

Details Analgesic compounds Analgesic compounds

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1201710

Abstract of the Disclosure A process for preparing a compound of the general formula Image (I) and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R1 is hydrogen, C1-C3 primary alkyl, or allyl; R2 is hydrogen or C1-C3 primary alkyl, subject to the limitation that when R1 is allyl, R2 is hydrogen; R3 is hydrogen or C1-C3 primary alkyl; R4 is C1-C4 primary or secondary alkyl; R5 is hydrogen or C1-C4 primary or secondary alkyl; R6 is hydrogen or C1-C3 primary alkyl; R7 is hydrogen or C1-C3 primary alkyl; Y is hydrogen or acetyl; Z is Image in which R8 is C1-C3 alkyl or hydrogen; and W is isopropyl, -VR9, or -CH2-X-CH3, in which V is O or S, R9 is C1-C4 alkyl or aralkyl, and X is O, S, or -CH2-, subject to the limitation that, when W is isopropyl, R7 is C1-C3 primary alkyl,and when W is -VR9, wherein V is S and R9 is methyl, then R8 is C1-C3 alkyl; which comprises cleaving the blocking agents from the correspondingly protected compound of formula (I) with a deblocking agent, as for example by the use of a substantially dry acid medium, is described herein. These compounds are useful as analgesic agents.

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