A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
128/104, 167/166
A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61M 31/00 (2006.01)
Patent
CA 1331563
(1) TITLE OF THE INVENTION Device for the Controlled Release of Drugs with Donnan-Like Modulation by Charged Insoluble Resins ABSTRACT OF THE INVENTION The instant invention relates to a drug-delivery device for the controlled release of a therapeutically active ingredient into an environment of use which comprises: (A) a core composition comprising (a) a water insoluble, non-diffusible charged resin entity, and (b) a diffusible water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and (2) - i - (B) an imperforate water insoluble wall surrounding said core composition and; prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall; or (C) a water insoluble wall surrounding said core composition and prepared from (i) a polymer material that is permeable to water but substantially impermeable to solute and (ii) 0.1 to 75% by weight, based on the total weight of (i) and (ii), of at least one water leachable pore forming additive dispersed throughout said wall.
573425
Goudreau Gage Dubuc
Merck & Co. Inc.
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