Method of inhibiting the activity of leukocyte derived...

Details Method of inhibiting the activity of leukocyte derived... Method of inhibiting the activity of leukocyte derived...

A - Human Necessities

61

K

167/220

A61K 31/52 (2006.01)

Patent

CA 1334508

A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula Image (I) in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals other than a 3-methyl-3-hydroxy butyl radi- cal, 3-methyl-3-hydroxy pentyl radical, or 4-methyl-4-hydroxy pentyl radical, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. The inhibition of IL-1, TNF, and other cytokines in mammals is impli- cated in alleviation of a wide variety of disease conditions.

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