Pyrazolo-pyrrolo-pyrimidine-diones

Details Pyrazolo-pyrrolo-pyrimidine-diones Pyrazolo-pyrrolo-pyrimidine-diones

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 471/14 (2006.01) C07D 487/14 (2006.01)

Patent

CA 1328866

ABSTRACT OF THE DISCLOSURE New pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of the formula I Image I where R1, R2, R3, R4 and m are as defined in the specification, e.g., 4-(benzoylmethyl)-6-cyclohexyl-6,7-dihydro-2-phenyl-4H-pyrazolo[1,5- a]pyrrolo[3,4-d]pyrimidine-5,8-dione, have been found to be poten- tially useful to trest warm-blooded animal patients suffering from the symptoms of atherosclerosis and cholesterol buildup to relieve the same and for favorably altering the high density lipoprotein (HDL) to low density lipoprotein (LDL) ratio in blood samples of such patients.

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