Stereospecific process for the preparation of furo ¬3,4-c|...

Details Stereospecific process for the preparation of furo ¬3,4-c|... Stereospecific process for the preparation of furo ¬3,4-c|...

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1338475

The invention relates to a stereospecific pro- cess for the preparation of enantiomers of 3-substituted- furo[3,4-c]pyridine of the general formula I Image I wherein R3 stands for a straight chain saturated or unsaturated hydrocarbon group having from 1 to 5 carbon atoms, a heterocyclic group having up to 6 ring atoms, a phenyl or cyclohexyl group, a phenylalkyl group or a phenylalkenyl group, each of said groups being optionally substituted by one or more chlorine bromine or fluorine atoms, trifluoromethyl groups, alkyl groups having from 1 to 5 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms, alkylthio groups having from 1 to 5 carbon atoms, dialkylamino groups in which each alkyl group has from 1 to 5 carbon atoms, dialkylaminoalkoxy groups in which each of the two alkyl groups and the alkoxy group has from 1 to 5 carbon atoms or an .alpha.- or .beta.-alkoxy-N-pyrrolidinyl group in which the alkoxy group has from 1 to 5 carbon atoms ; R4 stands for a hydrogen or a halogen atom and R6 stands for a straight chain or branched chain alkyl or alkenyl group having up to 6 carbon atoms, optionally substituted by a hydroxy, cyano, amino or substituted amino group or by an alkyl or alkenyl group having up to 4 carbon atoms.

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