Method for the determination of the activity of serine...

Details Method for the determination of the activity of serine... Method for the determination of the activity of serine...

C - Chemistry, Metallurgy

12

Q

150/9, 150/15.3

C12Q 1/37 (2006.01) C12Q 1/56 (2006.01)

Patent

CA 1338681

The invention relates to a method for the determination of the activity of serine proteases and serine protease inhibitors in plasma or other biological fluids. The only methods hitherto available for rapid and accurate determination of the content of serine proteases or serine protease inhibitors have been very time-consuming and methodologically demanding. In the method according to the invention for the determination of the activity of serine proteases or serine protease inhibitors, specific inhibitors are inactivated by addition of at least one oxidizing agent and, where appropriate, at least one detergent. The addition of an omega-aminocarboxylic acid enhances the observed effects when the serine protease is plasmin.

572353

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