Imidazolecarboxylic acid derivatives

Details Imidazolecarboxylic acid derivatives Imidazolecarboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

260/314.7

C07D 233/90 (2006.01)

Patent

CA 1182826

NOVEL IMIDAZOLECARBOXYLIC ACID DERIVATIVES ABSTRACT OF THE DISCLOSURE The use of novel imidazolecarboxylic acid derivatives of the following general structure which are useful as antihypertensives, cardiotonics and antithrombotics Image wherein Q and T are an oxygen or sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R1 is hydrogen or -CH(R3)R4; R2 is lower alkoxy, phenoxy or phenoxy substituted at the ortho, meta, or para position with lower alkyl, lower alkoxy, hydroxy, halogen, tri- fluoromethyl, lower alkylthio, lower alkylsulfone, or lower alkylsulfoxide; R3 is hydrogen or lower alkyl; R4 is hydrogen, hydroxy, lower alkoxy, lower alkyl- carbonyl, -ONO2 or halogen; and their pharmaceutically acceptable salts thereof.

414706

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