N-substituted mercaptoacyl propionamides

C - Chemistry – Metallurgy – 07 – D

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C07D 317/30 (2006.01) C07C 51/08 (2006.01) C07C 51/09 (2006.01) C07C 51/367 (2006.01) C07C 51/377 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1182818

Abstract Mammalian collagenase is inhibited by compounds having the formula Image or a salt thereof, wherein R1 is hydrogen, alkanoyl of 2 to 10 carbon atoms, or arylcarbonyl; Image 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1- piperazinyl or 4-alkyl-1-piperazinyl wherein R4 is hydrogen, alkyl or aryl; R3 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl; and n is an integer of 1 to 20.

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