Monoclonal antibody specific to a common determinant site of...

Details Monoclonal antibody specific to a common determinant site of... Monoclonal antibody specific to a common determinant site of...

C - Chemistry, Metallurgy

12

P

195/1.11

C12P 21/08 (2006.01) C07K 16/28 (2006.01)

Patent

CA 1297817

ABSTRACT OF THE DISCLOSURE A hybrid cell line capable of producing monoclonal antibodies uniquely specific to human neutrophils and eosinophils and exhibiting no specificity for lymphocytes, basophils and monocytes. Further there is no reactivity with acute leukemia cells. One of the partners in the hybridoma fu- sion of a mouse spleen cell developed from using human granulocytes as the immunization agent. The monoclonal antibody further is capable of being used to enumerate and isolate neutrophils in normal peripheral blood and possibly in blood of patients with acute leukemia.

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