Methods and compositions for protecting the gastrointestinal...

Details Methods and compositions for protecting the gastrointestinal... Methods and compositions for protecting the gastrointestinal...

A - Human Necessities

61

K

167/250

A61K 9/127 (2006.01)

Patent

CA 1310909

METHODS AND COMPOSITIONS FOR PROTECTING THE GASTROINTESTINAL TRACT ABSTRACT Disclosed are compositions composed of unique mix- tures of phospholipids and neutral lipids and methods of employing such compositions to treat the luminal lining of the gastrointestinal tract in the prevention or treatment of ulcerogenic processes such as peptic ulcer disease and inflammatory bowel disease. Compositions including mixtures of saturated or unsaturated phospholipids, together with saturated or unsaturated triglycerides and/or sterols, are shown to provide a surprising ulcer protective efficacy in experimental models. Further enhancement of activity is found upon the addition of a polyvalent cation or antioxidant to the various lipid mixtures.

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