Alkene, alkyne or cycloalkylene derivatives

Details Alkene, alkyne or cycloalkylene derivatives Alkene, alkyne or cycloalkylene derivatives

C - Chemistry, Metallurgy

07

D

260/260, 260/287

C07D 213/04 (2006.01) C07C 17/23 (2006.01) C07C 17/26 (2006.01) C07C 33/48 (2006.01) C07C 33/50 (2006.01) C07C 45/26 (2006.01) C07C 45/54 (2006.01) C07C 45/72 (2006.01) C07C 45/74 (2006.01) C07C 47/273 (2006.01) C07C 49/235 (2006.01) C07C 49/245 (2006.01) C07C 49/248 (2006.01) C07C 59/56 (2006.01) C07C 205/26 (2006.01) C07D 213/34 (2006.01) C07D 213/57 (2006.01) C07D 213/61 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 215/14 (2006.01) C07D 215/36 (2006.01) C07D 219/04 (2006.01) C07D 233/84 (20

Patent

CA 1269104

ABSTRACT A compound of the formula Image wherein X has the formula Image -CR5=CR6- -C?C- or wherein ring A is phenyl, naphthyl or an optionally substituted 5- or 6-membered heterocyclic; wherein R1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R2, R3 and R4, which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkyl- sulphinyl and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R2, R3 and R4 is an electron-withdrawing substituent; where- in R5 and R6, which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R7 is alkyl or halogenoalkyl; and where- in R8 is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogeno- alkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R8 is alkyl or alkenyl which bears one or more substituents selected from cyano, carbamoyl, amino, hydroxy, alkanoyl, alkoxy, alkylthio, alkenylthio, alkyl- sulphinyl, alkenylsulphinyl, alkylsulphonyl, alkenylsulphonyl, alkanoylamino, alkoxycarbonylamino, alkylsulphonamido, alkylamino, dialkylamino, dialkylsulphamoyl, aroyl, aryl, arylthio, arylsul- phinyl, arylsulphonyl, heterocyclylthio, heterocyclylsulphinyl and heterocyclylsulphonyl, the heterocyclic moiety being optionally substituted and 5- or 6-membered; or wherein R8 has the formula Image wherein ring .beta. is phenyl, naphthyl or heterocyclyl, the hetero- cyclic moiety being optionally substituted and 5- or 6-membered and wherein R2, R3 and R4 have any of the meanings stated above, provided that when R7 is methyl R8 is not also methyl. These compounds have antiandrogenic properties.

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