Fused azepinone and azocinone derivatives, processes for...

C - Chemistry – Metallurgy – 07 – D

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C07D 223/32 (2006.01) C07D 225/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1313371

HOE 87/F 048 Abstract of the Disclosure: Fused azepinone and azocinone derivatives, processes for their preparation, agents containing them and their use, and intermediates in their preparation The invention relates to compounds of the formula I Image (I) in which m denotes 1 or 2 and n denotes 0, 1 or 2; R1 and R2 denote identical or different radicals from the series comprising hydrogen, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, partly hydrogen- ated aryl and optionally substituted aralkyl; R3 and R4 denote identical or different radicals from the series com- prising hydrogen, alkyl, alkenyl and optionally substituted aralkyl; Y denotes hydrogen or hydroxyl and Z denotes hydro- gen, or Y and Z together denote oxo, and X denotes option- ally substituted alkyl, alkenyl, cycloalkyl, optionally sub- stituted 4-piperidinyl, optionally substituted aryl or indolyl, processes for their preparation, medicaments containing these compounds and their use in the treatment of hypertension or heart diseases, and to intermediates in their preparation.

558818

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