R(-)-10,11-alkylenedioxy-n-alkylnorapomorphine

C - Chemistry – Metallurgy – 07 – D

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C07D 491/056 (2006.01) A61K 31/485 (2006.01) C07D 221/18 (2006.01) C07D 489/02 (2006.01) C07D 491/06 (2006.01)

Patent

CA 1270253

Abstract of Disclosure A method for providing orally effective aporphine compounds, and new compounds which are orally effective in the prevention and treatment of duodenal ulcers and in the treat- ment of neurological and psychiatric disorders having the following formula Image wherein R1 is lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl, R2 and R3 are hydrogen, methyl, lower alkyl, substituted lower alkyl, cyclo- alkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl and R4 is hydrogen, hydroxy, -O-R5 and 0-?-R5 and R5 is methyl and lower alkyl. Particularly effective are compounds wherein R4 is hydrogen.

405440

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