Process for the preparation of cefodizime

Details Process for the preparation of cefodizime Process for the preparation of cefodizime

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/36 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/46 (2006.01) C07D 501/56 (2006.01)

Patent

CA 1287347

Abstract of the disclosure The invention relates to a process for the preparation of cefodizime of the formula Image (cefodizime) wherein (a) a compound of the formula II (ATS) Image wherein R1 represents-hydrogen or an aminoprotective group and A represents a hydrogen atom or one equiva- lent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first re- acted with a compound of the formula III R-SO2-Hal wherein R represents an alkyl, aryl or aralkyl radical which may be substituted and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base, (b) a compound of the formula I (TACS) Image in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appro- priate, in the presence of a base, and (c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R1 present in the end product of the formula I is eliminated.

524381

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