Stabilization of l-phenyl-alanine ammonia-lyase enzyme

Details Stabilization of l-phenyl-alanine ammonia-lyase enzyme Stabilization of l-phenyl-alanine ammonia-lyase enzyme

C - Chemistry, Metallurgy

12

N

195/38, 195/134.

C12N 9/88 (2006.01) C12N 9/96 (2006.01) C12N 11/10 (2006.01) C12P 13/22 (2006.01)

Patent

CA 1215012

STABILIZATION OF L-PHENYLALANINE AMMONIA-LYASE ENZYME ABSTRACT A process for the synthesis of L-phenylalanines and analogues thereof from trans-cinnamate, ring substituted trans-cinnamates or various acrylate derivatives and ammonia or an ammonia donor in the presence of L-phenylalanine ammonia-lyase enzyme and a desensitizing agent such as polyhydric alcohols and polyethylene glycol-(400) is disclosed. The process embraces the discovery that compounds such as polyhydric alcohols and polyethylene glycol-(400) desensitize the L-phenyalanine ammonia lyase enzyme to substantially higher substrate concentrations than practiced heretofore. In addition, polyhydric alcohols and polyethylene glycol-(400) substantially enhance the instantaneous rate of reaction and inhibit inactivation of the L-phenylalanine ammonia lyase enzyme over longer reaction periods.

462504

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