C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/16, 195/44,
C12Q 1/04 (2006.01)
Patent
CA 1179583
ABSTRACT OF THE DISCLOSURE, Molecules or cells of materials exhibiting a micro- biological activity, suppression or interaction of interest are isolated from a large population of similar molecules, cells or the like. The activity of the microbiologically active molecules or living matter of interest is measured by suspending the population in a liquid medium capable of forming a gel. The resultant suspension is formed into droplets which are caused to gel. The gel droplets (GMDs) are treated to effect desirable alteration of the micro- biologically active material and the amount of metabolites or reaction products of the desired alteration within each of the gel droplets. Alternatively, incubation is carried out such that each GMD initially containing one cell con- tains many, a microcolony, which can be tested for desirable properties while retaining sufficient viable cells for further growth and harvesting for further testing and/or production. The gel droplets are then separated based upon the measured or sensed characteristic, metabolite or reac- tion product.
403230
Massachusetts Institute Of Technology
Riches Mckenzie & Herbert Llp
LandOfFree
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