Therapeutic compositions and methods for manufacture and use

Details Therapeutic compositions and methods for manufacture and use Therapeutic compositions and methods for manufacture and use

C - Chemistry, Metallurgy

12

N

167/114

C12N 9/74 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1176563

Abstract of the Disclosure This is an improved method for producing activated prothrombin complex concentrate which comprises control- ling the degree of activation by determining the activa- tion state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation of the starting material to arrive at a predetermined activa- tion level. Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from l-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.

368717

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