Percutaneous absorption enhancer dispenser

Details Percutaneous absorption enhancer dispenser Percutaneous absorption enhancer dispenser

A - Human Necessities

61

M

167/159, 128/63

A61M 31/00 (2006.01) A61M 7/00 (1980.01)

Patent

CA 1183085

Abstract A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed at a therapeutically effective rate. A preferred embodiment delivers estradiol and employs ethanol as an enhancer, the ethanol delivery rate being about 100-800 mcg/hr/cm2 of skin surface.

445581

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