Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles

Details Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles

C - Chemistry, Metallurgy

07

C

167/251, 260/553

C07C 255/31 (2006.01) A61K 31/275 (2006.01)

Patent

CA 1314562

ABSTRACT Disclosed herein are novel .beta.-cycloalkyl-.beta.-oxopropioni- triles which exhibit anti-inflammatory/antiarthritic activities. Thus, there is disclosed a compound having the formula Image wherein n=2, 3, 4, or 5; A is C1-5alkyl, NHR1, or NR2R3; wherein R1 is selected from the group consisting of C1-5alkyl, C2-5alkenyl, C2-5alkynyl, and C3-6cycloalkyl with the proviso that when n is 2, R1 is not ethyl or isopropyl; and R2 and R3 are the same or different C1-5alkyl; or a pharmaceutically acceptable salt thereof.

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