Modified antibodies for enhanced clearance

Details Modified antibodies for enhanced clearance Modified antibodies for enhanced clearance

A - Human Necessities

61

K

167/139, 167/37

A61K 39/395 (2006.01) A61K 47/00 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1310264

Abstract of the Disclosure Antibodies and antibody conjugates which have been modified by conjugation to, or exposure thereon, of glycoside residues that bind to the human hepatic asialoglycoprotein receptor clear rapidly from the circulation. Use of such modified antibodies and antibody conjugates for imaging a therapy of tumors and infectious lesions is advantageous when the antibodies are administered by a regional route, or when intravenous adminstration is accompanied by injection of a competitive hepatic lectin binding inhibitor to control the rate of clearance and optimize uptake by the target tissues.

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