Process for the preparation of lmw-heparin

Details Process for the preparation of lmw-heparin Process for the preparation of lmw-heparin

C - Chemistry, Metallurgy

12

P

195/139

C12P 19/26 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1334080

A method for production of low molecular weight heparin (LMW-heparin) by enzymatic depolymerization of heparin with heparinase wherein heparin is continuously fed to a depolymerization zone, the depolymerized LMW-heparin is ultrafiltrated, the retentate is recycled to the depolymerization zone and LMW-heparin is recovered from the filtrate. The process enables the production of LMW-heparin with a desired molecular weight and low polydispersity within narrow limits by continuously or frequently measuring the molecular weight and polydispersity of the LMW-heparin product and correction of process parameters of the depolymerization reaction so as to counteract deviations in the molecular weight and polydispersity from the desired values.

536095

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