2-acylaminomethyl-1,4-benzodiazepine compounds, the...

Details 2-acylaminomethyl-1,4-benzodiazepine compounds, the... 2-acylaminomethyl-1,4-benzodiazepine compounds, the...

C - Chemistry, Metallurgy

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C07D 403/00 (2006.01) C07D 213/50 (2006.01) C07D 267/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1188299

ABSTRACT New 2-acylaminomethyl-1H-2,3-dihydro-1,4- benzodiazepine compounds are described having the general formula Image wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hydrogen atom, or a lower alkyl or alkenyl radical, n is 0, 1 or 2, R3 is an optionally sub- stituted furyl, thienyl, pyrrolyl, pyridyl or phenyl radical, R4 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical, R5 is a hydro- gen or halogen atom, or a lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifuloromethyl, cyano, amino, lower mono- or dialkylamino, lower mono- alkanoylamino, lower N-alkyl-N-alkanoylamino or lower alkanoyloxy radical, and R6 is a hvdrogen atom, or a lower alkyl or lower alkoxy radical or R5 and R6 together denote a methylenedioxy or ethylenedioxy radical. The compounds have pharmacological, for example, analgesic, properties.

405518

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