Thisazolopyrimidine derivatives

Details Thisazolopyrimidine derivatives Thisazolopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 513/04 (2006.01)

Patent

CA 1212109

ABSTRACT OF THE DISCLOSURE A process for preparing a thiazolopyrimidine derivative of the formula (I): Image (I) wherein R1 is a lower alkyl group, and R2 is a hydrogen atom or a lower alkyl group; which comprises the steps of: reacting 4,6-dichloro-2-methyl-5-nitropyrimidine with a dialkylamine of the formula (II): HN(R1)2 (II) to produce a compound of the formula (III): Image (III) substituting the chlorine atom on the pyrimidine ring of the compound of the formula (III) by a mercapto group by reaction with sodium hydrosulfide; reducing the nitro group on the pyrimidine ring to produce a compound of the formula (IV): Image (IV) and reacting the compound of the formula (IV) with an organic acid of the formula (V): R2.COOH (V) and if desired converting the resulting product into a pharmaceutically acceptable salt. The thiazolopyrimidine derivatives of the formula (I) have vasolidating action, hypotensive action, inhibitory action on platelet aggregation and decrease cholesterol levels in blood.

406376

Affiliated with

Also associated with

Rating

Thisazolopyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thisazolopyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thisazolopyrimidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1284201