Carbamate or urea derivatives, their preparation and...

C - Chemistry – Metallurgy – 07 – C

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260/546.2, 260/3

C07C 323/43 (2006.01) C07C 323/41 (2006.01) C07D 317/60 (2006.01)

Patent

CA 1277330

ABSTRACT A compound which is carbamate or urea derivative of general formula (I) Image (I) wherein X is hydrogen, halogen or methylthio, Y is oxygen or Image , R is C1-C4 alkyl, R1 is hydrogen, one or two halogen atoms or trifluoromethyl groups, a methyl group, a methoxy group, a cyano group, a nitro group, a methoxycarbonyl group, a methylenedioxy group linked to two adjacent carbon atoms of the benzene ring to which it is attached, or a fused benzo group forming an .alpha.-naphthyl or .beta.-naphthyl group with the benzene ring to which it is attached, R2 is a linear or branched C1-C8 alkyl or alkenyl group optionally substituted with halogen atoms or a methoxy group, a cyclopropylmethyl group, or a phenyl group optionally substituted with one or two halogen atoms or methyl groups, n is 1 or 2, and m is 2 or 3, or an addition salt thereof with a pharmacologically acceptable acid is pharmacologically active as a calcium antagonist.

541475

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