Tetrahydro-.beta.-carbolines, process for their production...

Details Tetrahydro-.beta.-carbolines, process for their production... Tetrahydro-.beta.-carbolines, process for their production...

C - Chemistry, Metallurgy

07

D

167/211, 260/276

C07D 471/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 1269981

ABSTRACT OF THE DISCLOSURE 5,6,7,8-tetrahydro-beta-carbolines derivatives of formula I Image (I) > wherein R1 is an oxadiazolyl radical of the formula Image , COOR3 or CONR4R5, R2 is H, lower alkyl, R3 is H or lower alkyl, R4 and R5 are H or lower alkyl, whereby R4 and R5 cannot be hydrogen at the same time, or R4 and R5 together with the adjacent nitrogen atom form a 5- or 6-member ring, which additionally can contain a heteroatom, and RA is hydrogen, =0, cycloalkyl, -COOR3 with R3 having the above-mentioned meanings, or lower alkyl, which optionally can be substituted by OH, halogen, lower alkoxy, phenyl, phenyloxy, -NR4R5, whereby R4 and R5 have the above-mentioned meanings, and RB can be hydrogen, lower alkyl or lower alkoxyalkyl, have valuable pharmacological properties.

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