Osmotic device for dispensing two different medications

Details Osmotic device for dispensing two different medications Osmotic device for dispensing two different medications

A - Human Necessities

61

M

128/104, 167/153

A61M 35/00 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1191761

ABSTRACT An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compart- ment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compart- ment by fluid being imbibed through the wall into each com- partment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time. The partition within the device dividing lumen into two compartments is substantially dimensionally stable.

423701

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