Process for the preparation of 2-substituted-5-...

Details Process for the preparation of 2-substituted-5-... Process for the preparation of 2-substituted-5-...

C - Chemistry, Metallurgy

07

D

260/259

C07D 239/50 (2006.01) C07D 239/46 (2006.01)

Patent

CA 1242198

ABSTRACT OF THE DISCLOSURE A process is disclosed for the preparation of 2-substituted-5-nitroso-4,6-diaminopyrimidines of the general formula: Image in which R represents aryl, alkyl, alkylthio, amino, substituted amino or arylalkyl, which comprises reacting malonic acid dinitrile with an amidine of the general formula: Image in which A represents chlorine,? SO4, HSO4, NO3, acetate or phosphate, and R has the meaning given above, in the presence of a nitrite salt under acidic conditions to form the corresponding amidine salt of isonitroso- malononitrile and thereafter converting this product with heating in the presence of an aprotic polar solvent and under basic conditions to form the desired end product.

524438

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