Pharmaceutical preparations

A - Human Necessities – 61 – K

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A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 47/00 (2006.01) A61K 47/18 (2006.01) C07D 213/20 (2006.01) C07D 213/30 (2006.01) C07D 213/63 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/69 (2006.01) C07D 213/73 (2006.01) C07D 213/80 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 233/54 (2006.01) C07D 235/06 (2006.01) C07D 239/26 (2006.01) C07D 239/30 (2006.01) C07D 239/36 (2006.01) C07D 239/46 (2006.01) C07D 239/47 (2006.01) C07D 239/54 (2006.01) C07D 239/553 (2006.01) C07D 241/2

Patent

CA 1321144

Abstract A pharmaceutical preparation is disclosed which is made up either of unilamellar or multilamellar vesicles or of a micelle consisting for both geometrical forms of a cationic tenside with a monovalent anion and an antiviral active sub- stance directed against reverse transcriptase, dispersed in a solvent whose pH value lies between 7.0 and 8.0, the critical micellization concentration (cmc), this applying to the vesi- cular forms as well, lying in the range of 1.0 x 10-7 to 1.5 x 10-5 mol/litre. The disclosed preparations have in par- ticular the advantage that the antiviral active substances after dissolution or the inhibited membranes can pass quanti- tatively (passively) into the cytoplasma through the N+ tensides (vesicular structure). They therefore permit inter alia a long-term therapy of ARC or AIDS complex.

543932

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