Chromans and chromenes

Details Chromans and chromenes Chromans and chromenes

C - Chemistry, Metallurgy

07

D

260/255, 260/300

C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1212946

Abstract Compounds o formula (I): Image (I) either one of R1 and R2 is hydrogen and the other is selected from the class of C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyloxy, C1-6 alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, C1-6 alkylsulphinyl, C1-6 alkylsulphonyl, C1-6 alkoxysulphinyl,C1-6 alkoxysulphonyl, C1-6 alkylcarbonylamino, C1-6 alkoxycarbonylamino, C1-6 alkyl-thiocarbonyl, C1-6 alkoxy-thiocarbonyl, C1-6 alkyl-thiocarbonyloxy, C1-6 alkyl-thiolmethyl, formyl or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety beingoptionally substituted by one or two C1-6 alkyl groups, or C1-6 alkylsulphinylamino, C1-6 alkylsulphonylaminoC1-6 alkoxysulphinylamino or C1-6 alkoxysulphonylamino or ethylenyl terminally substituted by C1-6 alkylcarbonyl, nitro or cyano, or -C(C1-6 alkyl)NOH or -C(C1-6 alkyl)NNH2, or one of R1 and R2 is nitro, cyano or C1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by one or two C1-6 alkyl or by C2-7 alkanoyl; - 2 - one of R3 and R4 is hydrogen or C1-4 alkyl and the other is C1-4 alkyl or R3 and R4 together are C2-5 polymethylene; either R5 is hydrogen, hydroxy, C1-6 alkoxy or C1-8 acyloxy and R6 is hydrogen or R5 and R6 together are a bond; Q is O or S; m is an integer from 0 to 2 and n is an integer from 0 to 2 such that m+n is 1 or 2; X is O or S, or N-R7, R7 being hydrogen, C1-9 alkyl, C2-7 alkanoyl, phenylC1-4 alkyl, naphthylcarbonyl, phenylcarbonyl or benzylcarbonyl optionally substituted in the phenyl or naphthyl ring by one or two C1-6 alkyl, C1-6 alkoxy or halogen; mono- or bi-cyclicheteroarylcarbonyl; the lactam or thiolactam group being trans to the R5 group when R5 and R6 are not a bond; or, when one or the other of R1 and R2 is an amino or an amino-containing group, or when X is NR7 and R7 is hydrogen, a pharmaceutically acceptable salt or solvate thereof having anti-hypertensive activity, a process for their preparation and their use as pharmaceuticals.

439125

Affiliated with

Also associated with

Rating

Chromans and chromenes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromans and chromenes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromans and chromenes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1289242