Process for the preparation of pyrimidinones and their acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/91 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1217768

Abstract Process for preparation of pyridimidinones of the general formula Image (I) wherein A and B together with both carbon atoms to which they are attached, represent an optionally substituted phenyl ring or a pyridine ring, D represents an alkylene or hydroxyalkylene group, R3 and R5 represent each a hydrogen atom or an alkyl group, R4 represents a hydrogen atom or an alkoxy group, and R6 represents an alkyl group, an alkylene or hydroxy- alkylene group optionally substituted on the ter- minal carbon atom by an optionally substituted phenyl or phenoxy group, and the salts thereof, showing valuable pharmacological properties, especially a hypotensive, antiarrhythmic and B- receptor blocking activity.

429507

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