Particle reagent size distribution measurements for immunoassay

G - Physics – 01 – N

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73/114, 73/59

G01N 21/51 (2006.01) G01N 33/543 (2006.01)

Patent

CA 1208938

PARTICLE REAGENT SIZE DISTRIBUTION MEASUREMENTS FOR IMMUNOASSAY ABSTRACT OF THE INVENTION A highly sensitive and rapid method for quantitatively assaying analytes in liquid media by directly measuring changes in particle size distribution of reagent particles having analyte insolubilized thereon in a system undergoing antibody-induced aggregation has been developed. The amount of analyte initially present can be determined by measuring the change in the distribution of particle size with time, the concentration of a particular size particle at a given time, the rate of formation of a particular size particle, or the steady-state maximum concentration for a particular size particle.

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