Pharmaceutical composition for implantation

Details Pharmaceutical composition for implantation Pharmaceutical composition for implantation

A - Human Necessities

61

K

167/180

A61K 47/00 (2006.01) A61K 9/20 (2006.01) A61K 31/575 (2006.01) A61L 27/54 (2006.01)

Patent

CA 1190475

ABSTRACT OF THE DISCLOSURE A noval pharmaceutical composition for implantation in a natural, pathological or artificial cavity in body tissue and which includes an antibiotic which is slowly released from the composition upon implantation, is provided herein. The pharmaceutical composition comprises CaSO4, e.g. Plaster of Paris or gypsum, and at least one antibiotic substance,e.g. fusidic acid or gentamycin or their respective pharmaceutical- ly-acceptable salts, selected for its ability to be slowly released from CaSO4 and to maintain antibiotically effective concentrations in fluid in the cavity for a period of up to several weeks. The preparation of the composition comprises forming a slurry of CaSO4,e.g. calcium sulphate hemihydrate, gypsum or Plaster of Paris, with the desired aforesaid anti- bacterial substance or substances and a suitable amount of sterile water, optionally adding specified auxiliary agent(s), and allowing the slurry obtained to set in moulds, or in situ.

396693

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