Pyrimidine derivatives, preparation thereof and use thereof

Details Pyrimidine derivatives, preparation thereof and use thereof Pyrimidine derivatives, preparation thereof and use thereof

C - Chemistry, Metallurgy

07

D

167/222, 260/255

C07D 239/46 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1256107

ABSTRACT OF THE DISCLOSURE PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF New pyrimidine derivatives of the formula: Image wherein Z is a group selected from Image in which R1 and R2 are each hydrogen, alkenyl, ar(lower)alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R5 is lower alkyl, R3 is hydrogen, aryl optionally substituted with lower alkyl, lower alkoxy and/or halogen, or pyridyl optionally substituted with lower alkyl, R4 is hydrogen, lower alkyl or phenyl optionally substituted with lower alkoxy, and Y is =O, =S or =N-R6, in which R6 is lower alkyl; cyclo(lower)alkyl; ar(lower)alkyl optionally substituted with lower alkoxy; N-containing unsaturated heterocyclic group optionally substituted with lower alkyl; or aryl optionally substituted with hydroxy, lower alkyl, halogen or lower alkoxy, in which lower alkoxy substituent may be substituted with epoxy, hydroxy, amino and/or lower alkylamino, provided that Y is =N-R6 when R3 and R4 are each hydrogen, and Y is =S or =N-R6 when R1 and R2 are each hydrogen or lower alkyl and R3 is phenyl, and pharmaceutically acceptable salts thereof, and processes for preparation thereof nad pharmaceutical composition comprising the same. These derivatives and salts thereof are useful as cardiotonic, antihypertensive agent, cerebrovascular vasodilator and anti-platelet agent.

450076

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