Atrial natriuretic factor

Details Atrial natriuretic factor Atrial natriuretic factor

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/58 (2006.01) C07K 14/47 (2006.01)

Patent

CA 1340622

Diuretic and natriuretic extracts, which have been characterized as peptide in nature, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid and may be prepared synthetically. After precipitation of impurities by pH adjustment, the extract may be further purified chromatographically. Extracts injected into test rats resulted in 30-40 fold increases in sodium and chloride excretions within 5 - 10 minutes of injection. Urine volume rose 10-15 fold and potassium excretion doubled. The response was complete in 20 minutes and no similar changes in renal function were observed following injection of a similarly obtained ventricular extract.

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