Derivatives of 2-amino-1,3,4,6,7,11b-hexahydro-2h-...

Details Derivatives of 2-amino-1,3,4,6,7,11b-hexahydro-2h-... Derivatives of 2-amino-1,3,4,6,7,11b-hexahydro-2h-...

C - Chemistry, Metallurgy

07

D

260/271.5

C07D 455/06 (2006.01)

Patent

CA 1253157

Abstract This reaction concerns benzoquinolizines of general formula (XIV) Image wherein R1 and R2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms and Z1 and Z2 are both hydrogen and R is hydrogen or lower alkyl or Z1 is hydrogen and Z2 is SO2R4 [where R4 is lower alkyl, halo(lower)alkyl, phenyl or phenyl substituted by one or more halogen, alkoxy, lower alkyl, alkylenedioxy, nitro, amino, acylamino, lower alkylamino, diloweralkylamino or trifluoromethyl substituents] or Z1 is SO2R3(where R3 is lower alkyl, halo(lower) alkyl, phenyl or phenyl substituted by one or more halogen, alkoxy, lower alkyl, alkylenedioxy, nitro, amino, acylamino, lower alkylamino, diloweralkylamino or trifluoromethyl substituents], Z2 is hydrogen and R is hydrogen. The compounds are useful as intermediates. for pharmacologically active benzoquinolizines.

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