Therapeutically useful imidazo¬1,2-.alpha.|pyridine derivatives

Details Therapeutically useful imidazo¬1,2-.alpha.|pyridine derivatives Therapeutically useful imidazo¬1,2-.alpha.|pyridine derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/271

C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01)

Patent

CA 1254207

- 26 - ABSTRACT Imidazo[1,2-a]pyridine derivatives of the general formula: Image wherein Y represents a hydrogen or halogen atom or a C1-4 alkyl radical, Z represents a furan-2-yl, thien-2-yl or pyridin-2-yl radical optionally carrying a halogen atom or a methyl or ethyl radical in the 5-position, and R represents the hydroxy radical, a C1-4 alkoxy radical or a group -NRlR2 in which R1 and R2 independently of one another each represent a hydrogen atom, a straight- or branched-chain C1-5 alkyl radical,optionally carrying one or more halogen atoms or a hydroxy radical, a group -N(C1-4 alkyl)2, a carbamoyl radical or a C1-4 alkoxy radical; the allyl radical, the propargyl radical; a C3-6 cycloalkyl radical, the benzyl radical; or the phenyl radical, or alternatively-NRlR2 together represent a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula Image in which X is 0, S, CHOR' or N-R", R' being a hydrogen atom or the benzyl radical and R" being a hydrogen atom, a C1-4 alkyl radical or the phenyl radical - 27 - optionally carrying a methoxy radical or a halogen atom, are new compounds. They are therapeutically useful as they possess anxiolytic, antianoxic, sleep-inducing, hypnotic and anticonvulsant properties.

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