C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/101
C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 277/593 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/22 (2006.01) C07F 7/10 (2006.01)
Patent
CA 1340604
There are described 7-(2-(2-aminothiazol- 4-yl)-2-hydroxyiminoacetamido]-3-cephem or salts thereof of the general formula: (see fig.I) wherein R1 is an organic group and R2 is carboxy or protected hydroxy. These compounds are prepared in high yield from the corresponding 7-amino-3-cephem compounds and 2-(2-aminothiazol-4-yl)-2-acyloxyiminoacetyl halide or a salt thereof. These compounds exhibit high antimicrobial activity, inhibiting the growth of a wide variety of pathogenic microorganisms including Gram-positive and Gram-negative microorganisms and are useful as antimicrobial agents. Intermediates useful for the preparation of these compounds are also described.
587693
Goto Jiro
Sakane Kazuo
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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