Process for the preparation of...

C - Chemistry – Metallurgy – 07 – D

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C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 277/593 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/22 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1340604

There are described 7-(2-(2-aminothiazol- 4-yl)-2-hydroxyiminoacetamido]-3-cephem or salts thereof of the general formula: (see fig.I) wherein R1 is an organic group and R2 is carboxy or protected hydroxy. These compounds are prepared in high yield from the corresponding 7-amino-3-cephem compounds and 2-(2-aminothiazol-4-yl)-2-acyloxyiminoacetyl halide or a salt thereof. These compounds exhibit high antimicrobial activity, inhibiting the growth of a wide variety of pathogenic microorganisms including Gram-positive and Gram-negative microorganisms and are useful as antimicrobial agents. Intermediates useful for the preparation of these compounds are also described.

587693

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