Process for the preparation of complex compounds

Details Process for the preparation of complex compounds Process for the preparation of complex compounds

C - Chemistry, Metallurgy

07

F

260/383, 260/425

C07F 5/00 (2006.01) C07C 259/06 (2006.01) C07D 241/08 (2006.01) C07D 417/04 (2006.01) C07F 13/00 (2006.01) C07F 15/02 (2006.01) C07F 19/00 (2006.01)

Patent

CA 1329208

Process for the preparation of complex compounds Abstract of the disclosure There is disclosed a process for the preparation of analytically pure chelate complexes which can be used in diagnostic medicine, for example as contrast media or radiopharmaceuticals. The process comprises trans- complexing a complex of a .beta.-dicarbonyl compound and a metal ion, for example a metal acetylacetonate, which is readily soluble in an organic solvent that is not miscible in all proportions with water, with a stoichiometric amount or with a less than equivalent amount of a chelat- ing agent whose binding affinity for the metal ion is greater than that of the .beta.-dicarbonyl compound.

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