Process for preparing immunogenic complex

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/44 (2006.01) A61K 45/00 (2006.01)

Patent

CA 1275246

TITLE: A PROCESS FOR PREPARING IMMUNOGENIC COMPLEX ABSTRACT OF HE DISCLOSURE The invention relates to a process for preparing immuno- genic complex containing antigens or antigenic determi- nants with hydrophobic domains, whereby viruses, mycoplas- mas, bacterias, parasites, animal cells, antigens or anti- genic determinants with hydrophobic domains are mixed with one or more solubilizing agents whereby complexes are formed between antigens or antigenic determinants and solubilizing agent, whereafter the antigens or antigenic det rminants are separated from solubilizing agent in the presence of, or are separated from the solubilizing agent and directly transferred to a glycoside solution, containing one or more glycosides with hydrophobic and hydrophilic domains in a concentration of at least the critical micellular concentration, thereby forming a protein complex which is isolated and purified, characterized in that lipids are added before the complex is isolated and purified.

520464

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