Recombinant gamma interferons having enhanced stability and...

Details Recombinant gamma interferons having enhanced stability and... Recombinant gamma interferons having enhanced stability and...

C - Chemistry, Metallurgy

12

N

530/13, 167/103.

C12N 15/23 (2006.01) A61K 38/21 (2006.01) C07K 14/57 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341573

The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus: (see figure I) wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.

470076

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