C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/261, 260/295
C07D 237/14 (2006.01) A61K 31/395 (2006.01) C07D 213/64 (2006.01) C07D 239/34 (2006.01)
Patent
CA 1266474
ABSTRACT An N-benzoyl urea compound having the formula: Image (I) wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is Image wherein Y1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is =CH- or a nitrogen atom, provided that one of A and B is =CH- and the other is a nitrogen atom, with the provisos (1) that when Q is Image wherein A is =CH-, Image is Image where when X is a hydrogen atom and Y1 is an alkyl group, Z is not a hydrogen atom, a halogen atom m or a trifluoromethyl group, and (2) that when Q is Image wherein A is a nitrogen atom and Y1 is a trifluoromethyl group, Y2 is other than a hydrogen atom. The compounds have huge antitumorous activities.
524940
Haga Takahiro
Koyanagi Toru
Okada Hiroshi
Sugi Hideo
Yamada Nobutoshi
Ishihara Sangyo Kaisha Ltd.
Marks & Clerk
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