Process for the preparation of cephem derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 501/16 (2006.01) C07C 237/06 (2006.01) C07D 498/08 (2006.01) C07D 519/06 (2006.01)

Patent

CA 1339738

A cephem derivative represented by the following formula: (see fig. I) wherein R1 means a fluorine-substituted lower alkyl and A1 denotes a cyclic or acyclic ammonio group, or a non-toxic salt thereof, is prepared by reacting a compound represented by the following formula: (see fig. II) wherein A1 has the same meaning as defined above, with another compound represented by the following formula: (see fig. III) wherein R1 has the same meaning as defined above, and if necessary, removing the protecting groups.

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