Thromboxane synthetase inhibitors, processes for their...

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C - Chemistry, Metallurgy

07

D

260/297, 260/305

C07D 213/54 (2006.01) C07D 209/08 (2006.01) C07D 209/10 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/50 (2006.01) C07D 213/55 (2006.01) C07D 213/57 (2006.01) C07D 307/79 (2006.01) C07D 307/80 (2006.01) C07D 307/82 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/62 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1178964

Abstract DEC 4 1984 Compounds of the formula:- Image (X) wherein R?, which is attached to a carbon atom of ring."B" is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl): Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2: X is O, S, NH, N(C1-C4 alkyl) or -CH-CH-; R, which is attached to a carbon atom of ring "B", is a group of the formulas:- Image or (3-pyridyl)-2- where Z is -CH2-, -CH-CH-, -OCH2-, -CO- or -S-; and the pharmaceutically acceptable salts thereof.1 The compounds in which Y is -COOH, -COO(C1-C4 alkyl) and -CONH2 are pharmaseutical agents being selective thromboxane bynthetese inhibitors. Those in which Y is -CH are useful intermediates.

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