Monoclonal antibody recognizing alpha 2 --> 3 bonds

Details Monoclonal antibody recognizing alpha 2 --> 3 bonds Monoclonal antibody recognizing alpha 2 --> 3 bonds

C - Chemistry, Metallurgy

12

P

167/45, 195/1.10

C12P 21/08 (2006.01) C07K 16/30 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/92 (2006.01)

Patent

CA 1337800

A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N- acetylneuraminic acid residue having alpha 2--> 3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N- acetylneuraminic acid residue having alpha 2--> 3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

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