Sulphonamidophenylcarboxylic acids and derivatives thereof

Details Sulphonamidophenylcarboxylic acids and derivatives thereof Sulphonamidophenylcarboxylic acids and derivatives thereof

C - Chemistry, Metallurgy

07

C

167/246, 260/472

C07C 311/00 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01)

Patent

CA 1241341

ABSTRACT OF THE DISCLOSURE Sulphonamides of the general formula: Image (I) in which R is a hydrogen atom or a lower alkyl radical, R1 is an alkyl radical or an aryl, aralkyl or aralkenyl radical, the aryl moiety of which in each case can be substituted one or more times by hydroxyl, halogen, trifluoromethyl, lower alkyl or alkoxy or by acyl, carboxy or alkoxycarbonyl, n is 1, 2 or 3 and W is a bond or an unbranched or branched divalent aliphatic hydrocarbon chain, which is either saturated or con- tains a double bond, as well as the physiologically acceptable salts, esters and amides thereof; display an excellent lipid-sinking action but also a pronounced inhibiting action on thrombocyte aggregation.

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