Method of diagnosing cartilage tissue abnormalities

Details Method of diagnosing cartilage tissue abnormalities Method of diagnosing cartilage tissue abnormalities

G - Physics

01

N

150/11, 167/37

G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1243261

METHOD OF DIAGNOSING CARTILAGE TISSUE ABNORMALITIES ABSTRACT OF THE DISCLOSURE It is found that abnormal levels of keratan sulfate in the peripheral blood are indicative of abnormalities of cartilage or cartilage-like tissues. Specifically, elevated levels of keratan sulfate in the peripheral blood plasma or serum are indicative of osteoarthritis and either substantially complete absence of or very elevated levels of keratan sulfate in the peripheral blood are indicative of macular dystrophy and related disorders. The level of keratan sulfate in the peripheral blood is determined by an immunoassay using a monoclonal antibody. Preferably the immunoassay employs a colorimetric reporter system.

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