Polyanhydrides with improved hydrolytic degradation properties

Details Polyanhydrides with improved hydrolytic degradation properties Polyanhydrides with improved hydrolytic degradation properties

C - Chemistry, Metallurgy

08

G

167/166, 402/296

C08G 67/04 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/765 (2006.01)

Patent

CA 1335858

Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxypheny- lalkanoic acids. These polymers are soluble in common organic solvents and have low metling points, generally in the range of 40-100°C. The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bio- active compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery. Furthermore, a desired degradation rate may be obtained by choosing the appropriate length of the aliphatic moiety.

571101

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